2-Bromo-5-chloropyridine

Name: 2-Bromo-5-chloropyridine
Brand: ChemScene
Availability: InStock
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CAS No. 40473-01-6
Cat. No. CS-W002545
Purity≥98%
MDL No.MFCD00234006

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Description

2-Bromo-5-chloropyridine is a halogenated pyridine derivative featuring complementary electrophilic sites at the 2- and 5-positions. This configuration enables selective cross-coupling reactions in C–C bond formation, particularly under palladium catalysis. The molecule exhibits enhanced stability and solubility in common organic solvents, facilitating use in synthetic sequences for pharmaceutical intermediates and functional materials.

Application

2-Bromo-5-chloropyridine serves as a versatile building block in heterocyclic synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The bromo group facilitates C–C bond formation under standard Suzuki, Stille, or Negishi conditions, while the chloro substituent remains inert, allowing for sequential functionalization. Bench-stable and readily purified by distillation, it supports scalable synthesis of pharmaceutical intermediates and agrochemical scaffolds.

General Information

CAS No. 40473-01-6
Cat. No. CS-W002545
Purity ≥98%
MDL No. MFCD00234006
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₃BrClN
Molecular Weight 192.44
Synonym(s) 2-Bromo-5-chloro-pyridine
SMILES BrC1=NC=C(Cl)C=C1

Computational Chemistry Data

TPSA 12.89
LogP 2.4975
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05,GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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2-Bromo-5-chloropyridine

CAS No. 40473-01-6

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