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Structure of 40473-07-2
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2-Bromo-6-(methyloxy)pyridine is a bench-stable, moisture-tolerant heterocyclic building block featuring a bromine at the C2 position and a methoxy group at C6. This electronic and steric configuration enables efficient cross-coupling reactions in late-stage functionalization, particularly in Suzuki-Miyaura and Negishi transformations. The para-oriented substituents enhance regioselectivity and stability during catalytic processes.
2-Bromo-6-(methyloxy)pyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient construction of substituted pyridine scaffolds. Its bromine substituent facilitates palladium-catalyzed coupling reactions with boronic acids and amines, while the methoxy group provides moderate electron-donating character and ortho-directing capability. The compound exhibits good bench stability and is compatible with standard reaction conditions, making it well-suited for medicinal chemistry and process development workflows requiring selective functionalization of heterocyclic cores.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
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Lot numbers can be found on the outside label of a product: