6-Chloro-3-pyridinesulfonamide

Name: 6-Chloro-3-pyridinesulfonamide
Brand: ChemScene
Availability: InStock
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CAS No. 40741-46-6
Cat. No. CS-W008954
Purity≥96%
MDL No.MFCD00661410

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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6-Chloro-3-pyridinesulfonamide|CS-W008954

Structure of 40741-46-6

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Description

6-Chloro-3-pyridinesulfonamide features a chlorine-substituted pyridine ring paired with a sulfonamide group, delivering enhanced electron-withdrawing character and improved solubility in polar solvents. This combination enables robust participation in transition metal-catalyzed coupling reactions and facilitates incorporation into bioactive scaffolds requiring precise electronic tuning and metabolic stability.

Application

6-Chloro-3-pyridinesulfonamide serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the 6-position via palladium-catalyzed cross-coupling reactions. Its sulfonamide group provides enhanced solubility and hydrogen-bonding capacity, while the chloropyridine moiety offers predictable reactivity in nucleophilic substitution and transition-metal-catalyzed transformations. The compound exhibits excellent bench stability and facilitates rapid access to diverse heterocyclic scaffolds relevant to kinase inhibitor and CNS-targeted drug discovery programs.

General Information

CAS No. 40741-46-6
Cat. No. CS-W008954
Purity ≥96%
MDL No. MFCD00661410
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₅ClN₂O₂S
Molecular Weight 192.62
Synonym(s) 2-Chloro-5-pyridinesulfonamide; 6-Chloropyridine-3-sulfonamide
SMILES O=S(C1=CC=C(Cl)N=C1)(N)=O

Computational Chemistry Data

TPSA 73.05
LogP 0.3824
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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6-Chloro-3-pyridinesulfonamide

CAS No. 40741-46-6

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