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Structure of 40757-09-3
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Methyl 5-iodo-2-methoxybenzoate features a sterically hindered, electron-deficient aromatic core with orthogonal methoxy and iodide substituents. This configuration enables selective cross-coupling reactions under standard conditions, delivering complex heterocyclic scaffolds with high functional group tolerance. The methyl ester facilitates downstream derivatization, while the para-positioned iodide ensures efficient palladium-catalyzed transformations.
Methyl 5-iodo-2-methoxybenzoate serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient access to substituted aromatic scaffolds. The iodide group facilitates reliable coupling with boronic acids, stannanes, and amines under standard Pd-catalyzed conditions, while the methoxy and ester functionalities provide orthogonal handles for further derivatization. Bench-stable and readily purified by flash chromatography, it supports scalable synthesis of complex intermediates for medicinal chemistry and materials applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: