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Structure of 40899-71-6
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1-(Phenylsulfonyl)-1H-indole features a sulfonated indole core with a phenyl group appended to the sulfonyl moiety, delivering enhanced solubility and stability. This configuration enables efficient integration into heterocyclic scaffolds for medicinal chemistry applications, particularly in kinase inhibitor design and bioactive molecule synthesis under standard conditions.
1-(Phenylsulfonyl)-1H-indole serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the indole C3 position via electrophilic substitution. Its phenylsulfonyl group enhances solubility and provides a robust handle for subsequent transformations, including Suzuki-Miyaura coupling and nucleophilic displacement. The molecule exhibits excellent bench stability and facilitates purification by flash chromatography, making it well-suited for iterative synthesis of heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: