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CS-W001157 4
Total: USD 88.00

3-Fluoro-4-biphenylboronic acid

  • CAS No. 409108-13-0

  • Cat. No. CS-0030007
  • Purity≥98%
  • MDL No.MFCD04115668

*For research and further manufacturing use only, not for direct human use.

3-Fluoro-4-biphenylboronic acid|CS-0030007

Structure of 409108-13-0

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General Information

  • CAS No. 409108-13-0
  • Cat. No. CS-0030007
  • Purity ≥98%
  • MDL No. MFCD04115668
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₀BFO₂
  • Molecular Weight 216.02
  • Synonym(s) 3-Fluoro-4-biphenylboronicaci
  • SMILES FC1=CC(C2=CC=CC=C2)=CC=C1B(O)O

Description

3-Fluoro-4-biphenylboronic acid delivers a fluorinated aryl boronate moiety for Suzuki-Miyaura cross-coupling, combining enhanced stability with favorable reactivity. The para-fluorine substituent modulates electronic properties and improves metabolic resistance, enabling efficient C–C bond formation under standard conditions.

Application

3-Fluoro-4-biphenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds. Its fluorinated aryl group enhances metabolic stability and modulates electronic properties in pharmaceutical intermediates. The boronic acid functionality offers excellent bench stability, mild reaction conditions, and compatibility with diverse functional groups, facilitating streamlined synthesis of complex heterocycles and drug candidates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   1.1725
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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