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CS-W001157 4
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1-(Thiazol-2-yl)ethan-1-ol

  • CAS No. 40982-30-7

  • Cat. No. CS-0179471
  • Purity≥98%
  • MDL No.MFCD13184171

*For research and further manufacturing use only, not for direct human use.

1-(Thiazol-2-yl)ethan-1-ol|CS-0179471

Structure of 40982-30-7

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General Information

  • CAS No. 40982-30-7
  • Cat. No. CS-0179471
  • Purity ≥98%
  • MDL No. MFCD13184171
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇NOS
  • Molecular Weight 129.18
  • Synonym(s) 1-Thiazol-2-yl-ethanol
  • SMILES OC(C)C1=NC=CS1

Description

1-(Thiazol-2-yl)ethan-1-ol features a thiazole ring linked to a primary alcohol via a methylene bridge, delivering a polar yet lipophilic scaffold. This configuration supports hydrogen bonding and facilitates integration into bioactive molecules. The compound exhibits bench-stable handling characteristics and serves as a key intermediate in synthesizing heterocyclic pharmaceuticals and functional materials.

Application

1-(Thiazol-2-yl)ethan-1-ol serves as a versatile building block for thiazole-containing scaffolds, enabling efficient access to bioactive heterocycles. Its hydroxyl group facilitates derivatization via etherification or oxidation, while the adjacent thiazole ring provides robust stability and compatibility with standard coupling reactions. The compound exhibits favorable bench stability and ease of purification, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Battilocchio, Claudio; Hawkins, Joel M.; Ley, Steven V. Organic Letters, 2013 , vol. 15, # 9 p. 2278 - 2281
  • Route2
    • In-stock
      2-Bromothiazole|CS-W001223
      3034-53-5
    • null|null
      75-07-0
    • ~%
    • In-stock
      1-(Thiazol-2-yl)ethan-1-ol|CS-0179471
      40982-30-7

    References

    • Noyce,D.S.; Fike,S.A. Journal of Organic Chemistry, 1973 , vol. 38, p. 3316 - 3318
  • Route3
    • null|null
      134271-26-4
    • ~80%
    • In-stock
      1-(Thiazol-2-yl)ethan-1-ol|CS-0179471
      40982-30-7

    References

    • Jones, Gurnos; Ollivierre, Hermione; Fuller, L. S.; Young, J. H. Tetrahedron, 1991 , vol. 47, # 16 p. 2851 - 2860

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.1964
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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