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6-Methoxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid

  • CAS No. 410090-04-9

  • Cat. No. CS-0490150
  • Molecule weight169.13
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Methoxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid|CS-0490150

Structure of 410090-04-9

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General Information

  • CAS No. 410090-04-9
  • Cat. No. CS-0490150
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₄
  • Molecular Weight 169.13
  • Synonym(s) 6-Methoxy-2-oxo-1H-pyridine-3-carboxylic acid
  • SMILES COC1NC(=O)C(C(O)=O)=CC=1

Description

6-Methoxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid features a fused pyridine core with orthogonal functional groups enabling direct integration into heterocyclic synthesis. The methoxy substituent enhances solubility and modulates electronic properties, while the carboxylic acid facilitates coupling reactions. This bench-stable scaffold serves as a key intermediate in the construction of bioactive nitrogen-containing compounds.

Application

6-Methoxy-2-oxo-1,2-dihydropyridine-3-carboxylic acid serves as a versatile building block in heterocyclic synthesis, enabling efficient access to pyridine-based scaffolds through standard functional group manipulations. Its ortho-dicarbonyl architecture facilitates palladium-catalyzed couplings and cyclization reactions, while the methoxy and carboxylic acid groups provide handle points for derivatization. Bench-stable and readily purified by recrystallization, it supports scalable workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   79.39
  • LogP   0.0817
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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