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Structure of 412348-27-7
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tert-Butyl 4-(6-bromopyridin-3-yl)piperazine-1-carboxylate features a brominated pyridine moiety appended to a piperazine core, enabling direct integration into cross-coupling reactions. The tert-butyl carbamate group offers stability and convenient deprotection under mild acidic conditions. This compound serves as a key intermediate in the synthesis of bioactive molecules, particularly in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.
tert-Butyl 4-(6-bromopyridin-3-yl)piperazine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The bromopyridine moiety facilitates Suzuki, Stille, and Negishi couplings, while the piperazine scaffold provides a polar, basic nitrogen for hydrogen bonding and solubility enhancement. The tert-butyl carbamate group offers stability during storage and purification, and can be selectively removed under mild acidic conditions to reveal the free piperazine amine. This compound exhibits excellent bench stability, compatibility with diverse reaction conditions, and predictable reactivity in standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: