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CS-W001157 4
Total: USD 88.00

1H-1,2,3-Benzotriazol-1-ylacetic acid

  • CAS No. 4144-64-3

  • Cat. No. CS-0060599
  • Purity≥97%
  • MDL No.MFCD00553342
  • HazMat Fee +

    HazMat Fee

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1H-1,2,3-Benzotriazol-1-ylacetic acid|CS-0060599

Structure of 4144-64-3

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Description

1H-1,2,3-Benzotriazol-1-ylacetic acid features a benzotriazole moiety linked to a carboxylic acid group, enabling efficient coupling in peptide synthesis. This derivative combines the activating power of benzotriazole with enhanced solubility and stability under standard conditions, facilitating clean reaction profiles and high yields in amide bond formation.

Application

1H-1,2,3-Benzotriazol-1-ylacetic acid serves as a versatile acylating agent in peptide synthesis and small-molecule conjugation, enabling efficient formation of amide bonds under mild conditions. Its benzotriazole leaving group ensures high reactivity with nucleophiles while maintaining bench stability and ease of purification. Functions effectively in standard coupling protocols, offering good functional group tolerance and compatibility with common protecting groups in complex molecule assembly.

General Information

  • CAS No. 4144-64-3
  • Cat. No. CS-0060599
  • Purity ≥97%
  • MDL No. MFCD00553342
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇N₃O₂
  • Molecular Weight None
  • Synonym(s) Benzotriazol-1-yl-acetic acid
  • SMILES C1=CC=C2C(=C1)N=NN2CC(=O)O

Computational Chemistry Data

  • TPSA   68.01
  • LogP   0.5159
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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