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Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

5,6-Dichloronicotinic acid Avatrombopag Impurity

  • CAS No. 41667-95-2

  • Cat. No. CS-0377431
  • Purity≥98%
  • MDL No.MFCD00075181

*For research and further manufacturing use only, not for direct human use.

5,6-Dichloronicotinic acid Avatrombopag Impurity|CS-0377431

Structure of 41667-95-2

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General Information

  • CAS No. 41667-95-2
  • Cat. No. CS-0377431
  • Purity ≥98%
  • MDL No. MFCD00075181
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃Cl₂NO₂
  • Molecular Weight 192.00
  • Synonym(s) None
  • SMILES O=C(C1=CC(Cl)=C(Cl)N=C1)O

Synthesis

  • Route1
    • Ethyl 5,6-dichloronicotinate|CS-W014259
      401566-69-6
    • ~93%
    • 5,6-Dichloronicotinic acid Avatrombopag Impurity|CS-0377431
      41667-95-2

    References

    • XENON PHARMACEUTICALS INC.; GENENTECH, INC; Chowdhury, Sultan; Dehnhardt, Christoph Martin; Focken, Thilo; Grimwood, Michael Edward; Hemeon, Ivan William; Jia, Qi; Ortwine, Daniel; Safina, Brian; Sun, Shaoyi; Sutherlin, Daniel P.; Zenova, Alla Yurevna Patent: US2013/317000 A1, 2013 ; Location in patent: Paragraph 0368-0369 ;
  • Route2

    References

    • Raeth; Schiffmann Justus Liebigs Annalen der Chemie, 1931 , vol. 487, p. 127,129
  • Route3
    • 5-Chloro-6-oxo-1,6-dihydropyridine-3-carboxylic acid Avatrombopag Impurity|CS-0377312
      54127-63-8
    • null|null
      10026-13-8
    • null|null
      10025-87-3
    • ~%
    • 5,6-Dichloronicotinic acid Avatrombopag Impurity|CS-0377431
      41667-95-2

    References

    • v. Pechmann; Mills Chemische Berichte, 1904 , vol. 37, p. 3830

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.0866
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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