2,5-Dimethylthiazole

Name: 2,5-Dimethylthiazole
Brand: ChemScene
Availability: InStock
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CAS No. 4175-66-0
Cat. No. CS-W002408
Purity≥98%
MDL No.MFCD00130120

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 4175-66-0

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Description

2,5-Dimethylthiazole serves as a valuable heterocyclic scaffold in medicinal chemistry and synthetic methodology. This bench-stable, electron-rich thiazole derivative features methyl groups at the 2- and 5-positions, enhancing its lipophilicity and metabolic stability. It integrates readily into bioactive molecules, particularly in kinase inhibitors and antiparasitic agents. The fused ring system provides a rigid, planar framework ideal for target engagement.

Application

2,5-Dimethylthiazole serves as a versatile heterocyclic building block in medicinal chemistry and catalyst design. Its stable, electron-rich core facilitates palladium-catalyzed cross-coupling reactions and functions as a key scaffold in bioactive molecule synthesis. The methyl groups enhance solubility and metabolic stability, while the thiazole ring provides robustness under standard reaction conditions. This compound enables efficient access to complex architectures via functionalization at C-4 or C-2 positions.

General Information

CAS No. 4175-66-0
Cat. No. CS-W002408
Purity ≥98%
MDL No. MFCD00130120
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₇NS
Molecular Weight 113.18
Synonym(s) 5-DiMethylthiazole
SMILES Cc1ncc(s1)C

Computational Chemistry Data

TPSA 12.89
LogP 1.75994
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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2,5-Dimethylthiazole

CAS No. 4175-66-0

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