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CS-W001157 4
Total: USD 88.00

2,5-Dimethylthiazole

  • CAS No. 4175-66-0

  • Cat. No. CS-W002408
  • Molecule weight113.18
  • Purity≥98%
  • MDL No.MFCD00130120

*For research and further manufacturing use only, not for direct human use.

2,5-Dimethylthiazole|CS-W002408

Structure of 4175-66-0

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General Information

  • CAS No. 4175-66-0
  • Cat. No. CS-W002408
  • Purity ≥98%
  • MDL No. MFCD00130120
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇NS
  • Molecular Weight 113.18
  • Synonym(s) 5-DiMethylthiazole
  • SMILES Cc1ncc(s1)C

Description

2,5-Dimethylthiazole serves as a valuable heterocyclic scaffold in medicinal chemistry and synthetic methodology. This bench-stable, electron-rich thiazole derivative features methyl groups at the 2- and 5-positions, enhancing its lipophilicity and metabolic stability. It integrates readily into bioactive molecules, particularly in kinase inhibitors and antiparasitic agents. The fused ring system provides a rigid, planar framework ideal for target engagement.

Application

2,5-Dimethylthiazole serves as a versatile heterocyclic building block in medicinal chemistry and catalyst design. Its stable, electron-rich core facilitates palladium-catalyzed cross-coupling reactions and functions as a key scaffold in bioactive molecule synthesis. The methyl groups enhance solubility and metabolic stability, while the thiazole ring provides robustness under standard reaction conditions. This compound enables efficient access to complex architectures via functionalization at C-4 or C-2 positions.

Synthesis

  • Route1
    • In-stock
      2-Methylthiazole|CS-W002260
      3581-87-1
    • null|null
      74-88-4
    • ~%
    • In-stock
      2,5-Dimethylthiazole|CS-W002408
      4175-66-0

    References

    • Eisai RandD Management Co., Ltd. Patent: US2011/86882 A1, 2011 ; Location in patent: Page/Page column 34 ; US 20110086882 A1
  • Route2
    • In-stock
      Acetamide|CS-0015934
      60-35-5
    • null|null
      19967-57-8
    • ~%
    • In-stock
      2,5-Dimethylthiazole|CS-W002408
      4175-66-0

    References

    • Poite,M.; Metzger,J. Bulletin de la Societe Chimique de France, 1962 , p. 2078 - 2085
  • Route3

    References

    • Jur'ew; Shukowa Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 7,10; engl. Ausg. S. 5, 7

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.75994
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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