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Structure of 417712-26-6
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Methyl (E)-3-(3-formyl-4-hydroxyphenyl)acrylate features a conjugated enone system flanked by a phenolic hydroxyl and aldehyde functional group, enabling direct participation in Diels-Alder cycloadditions and nucleophilic addition reactions. The ester moiety enhances solubility in polar organic solvents while maintaining stability under standard bench conditions. This scaffold serves as a key intermediate for bioactive molecule synthesis.
Methyl (E)-3-(3-formyl-4-hydroxyphenyl)acrylate serves as a versatile building block for the synthesis of bioactive heterocycles and natural product analogs. The conjugated enal–ester system enables reliable Michael additions, aldol condensations, and transition-metal-catalyzed coupling reactions. The phenolic hydroxyl group provides a site for selective derivatization, while the aldehyde functionality supports reductive amination and oxime formation. Bench-stable and amenable to standard purification methods, it facilitates efficient access to complex scaffolds in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: