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CS-W001157 4
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O-(tert-Butyldimethylsilyl)hydroxylamine

  • CAS No. 41879-39-4

  • Cat. No. CS-0343137
  • Molecule weight147.29
  • Purity≥95%
  • MDL No.MFCD00054944

*For research and further manufacturing use only, not for direct human use.

O-(tert-Butyldimethylsilyl)hydroxylamine|CS-0343137

Structure of 41879-39-4

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General Information

  • CAS No. 41879-39-4
  • Cat. No. CS-0343137
  • Purity ≥95%
  • MDL No. MFCD00054944
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₇NOSi
  • Molecular Weight 147.29
  • Synonym(s) OtertButyldiemthylsilylhydroxylamine
  • SMILES NO[Si](C)(C(C)(C)C)C

Description

O-(tert-Butyldimethylsilyl)hydroxylamine (tert-butyldimethylsilyl-O-hydroxylamine) may be used to induce the cleavage, during solid supported synthesis of hydroxamic acids.

Application

O-(tert-Butyldimethylsilyl)hydroxylamine serves as a stable, bench-friendly silyl protecting group for hydroxylamines, enabling selective protection and deprotection under mild conditions. It facilitates the synthesis of oxime derivatives and functions as a key building block in the construction of nitrogen-containing heterocycles and bioactive scaffolds. Its excellent functional group tolerance and compatibility with standard synthetic protocols make it a practical choice for complex molecule assembly.

Synthesis

  • Route1
    • null|null
      18162-48-6
    • ~66%
    • In-stock
      O-(tert-Butyldimethylsilyl)hydroxylamine|CS-0343137
      41879-39-4

    References

    • Organic and Biomolecular Chemistry, , vol. 4, # 22 p. 4178 - 4185

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.25
  • LogP   1.8819
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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