2-Chloro-8-methylquinoline

Name: 2-Chloro-8-methylquinoline
Brand: ChemScene
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CAS No. 4225-85-8
Cat. No. CS-W021670
Purity≥98%
MDL No.MFCD11108682

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 4225-85-8

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Description

2-Chloro-8-methylquinoline is a heterocyclic compound featuring a quinoline core with strategically positioned chlorine and methyl substituents. This electron-deficient scaffold integrates readily into transition metal-catalyzed coupling reactions, serving as a robust ligand in palladium-mediated transformations. The steric profile and electronic tuning offered by the 2-chloro and 8-methyl groups enhance coordination stability and reactivity control in catalytic systems.

Application

2-Chloro-8-methylquinoline serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive C–Cl bond and electron-deficient quinoline core. The 8-methyl group enhances regioselectivity in subsequent functionalizations, while the molecule exhibits bench stability and ease of purification. It functions as a key scaffold for constructing bioactive heterocycles and pharmaceutical intermediates.

General Information

CAS No. 4225-85-8
Cat. No. CS-W021670
Purity ≥98%
MDL No. MFCD11108682
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₈ClN
Molecular Weight 177.63
Synonym(s) Quinoline, 2-chloro-8-methyl-
SMILES CC1=C2N=C(Cl)C=CC2=CC=C1

Computational Chemistry Data

TPSA 12.89
LogP 3.19662
H_Acceptors 1
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds quinoline compounds

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2-Chloro-8-methylquinoline

CAS No. 4225-85-8

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