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CS-W001157 4
Total: USD 88.00

2,2',4'-Trichloroacetophenone

  • CAS No. 4252-78-2

  • Cat. No. CS-0008216
  • Purity≥98%
  • MDL No.MFCD00000934

*For research and further manufacturing use only, not for direct human use.

2,2',4'-Trichloroacetophenone|CS-0008216

Structure of 4252-78-2

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General Information

  • CAS No. 4252-78-2
  • Cat. No. CS-0008216
  • Purity ≥98%
  • MDL No. MFCD00000934
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅Cl₃O
  • Molecular Weight 223.48
  • Synonym(s) None
  • SMILES ClC1=CC=C(C(CCl)=O)C(Cl)=C1

Description

2,2',4'-Trichloroacetophenone is a chlorinated aromatic ketone featuring three chlorine atoms positioned at the 2, 2', and 4' ring sites. This electron-deficient aryl moiety enables selective electrophilic reactions in synthetic pathways. The compound exhibits enhanced stability under standard bench conditions and serves as a key intermediate in the construction of complex heterocycles and functionalized arenes.

Synthesis

  • Route1
    • 1-(2,4-Dichlorophenyl)ethan-1-one Ketoconazole Impurity|CS-0528658
      2234-16-4
    • ~75%
    • 2,2-Dichloro-1-(2,4-dichlorophenyl)ethanone|CS-0206599
      2274-66-0
    • In-stock
      2,2',4'-Trichloroacetophenone|CS-0008216
      4252-78-2

    References

    • Prakash, G.K. Sxurya; Ismail, Rehana; Garcia, Jessica; Panja, Chiradeep; Rasul, Golam; Mathew, Thomas; Olah, George A. Tetrahedron Letters, 2011 , vol. 52, # 11 p. 1217 - 1221
  • Route2
    • null|null
      79-04-9
    • null|null
      541-73-1
    • ~%
    • In-stock
      2,2',4'-Trichloroacetophenone|CS-0008216
      4252-78-2

    References

    • Zhan, Peng; Liu, Xinyong; Cao, Yuan; Wang, Yan; Pannecouque, Christophe; De Clercq, Erik Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 20 p. 5368 - 5371
  • Route3
    • null|null
      15289-81-3
    • ~%
    • In-stock
      2,2',4'-Trichloroacetophenone|CS-0008216
      4252-78-2

    References

    • Pilgram,K. et al. Journal of Organic Chemistry, 1969 , vol. 34, p. 3558 - 3561

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3335
Class : 9
Packing Group : Ⅲ
Hazard Statements : H315-H317-H318-H335
Precautionary Statements : P261-P264-P271-P272-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.4149
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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