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Structure of 425379-16-4
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2-Bromo-3-fluorobenzonitrile features a strategically positioned nitrile group flanked by bromo and fluoro substituents, enabling direct functionalization in cross-coupling and electrophilic substitution reactions. This electron-deficient aryl halide exhibits enhanced reactivity under standard conditions, offering efficient access to complex heterocyclic scaffolds in medicinal chemistry and materials science.
2-Bromo-3-fluorobenzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The nitrile group provides a handle for downstream functionalization, while the ortho-bromine facilitates Suzuki, Stille, or Negishi couplings. Bench-stable and readily purified by distillation, it functions reliably in multi-step syntheses requiring precise regiocontrol.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: