Bis-Tos-PEG6

Name: Bis-Tos-PEG6
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 42749-27-9
Cat. No. CS-0114360
Purity≥98%
MDL No.MFCD00319275

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HazMat Fee

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The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 42749-27-9

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Description

Bis-Tos-PEG6 features a bis-tosylated core linked by a hexaethylene glycol spacer, offering enhanced solubility and stability in aqueous and polar organic media. This bifunctional reagent enables efficient conjugation workflows in bioconjugation and polymer synthesis, where precise spacing and robust linkage are required.

Application

Bis-Tos-PEG6 serves as a versatile bifunctional linker in synthetic organic chemistry, enabling efficient conjugation of active pharmaceutical ingredients and biomolecules. Its PEG6 spacer provides enhanced solubility and reduced aggregation, while the Tosyl (Tos) groups offer reliable activation for nucleophilic substitution under mild conditions. The molecule demonstrates excellent bench stability and compatibility with diverse functional groups, facilitating straightforward purification and integration into standard peptide and small-molecule synthesis workflows.

General Information

CAS No. 42749-27-9
Cat. No. CS-0114360
Purity ≥98%
MDL No. MFCD00319275
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₆H₃₈O₁₁S₂
Molecular Weight 590.70
Synonym(s) None
SMILES O=S(C1=CC=C(C)C=C1)(OCCOCCOCCOCCOCCOCCOS(C2=CC=C(C)C=C2)(=O)=O)=O

Computational Chemistry Data

TPSA 132.89
LogP 2.49724
H_Acceptors 11
H_Donors 0
Rotatable_Bonds 22

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Other Classifications

Building Blocks Functional Group PEG

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science Linker PEG Tosylate

Chemical Biology PEGylation Monofunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation Heterobifunctional PEG and Oligoethylene Glycols

Chemical Biology PEGylation PEG Oligomers

Biochemistry Biochemicals and Reagents Bioconjugation PEGylation Reagents and PEG Spacers

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Bis-Tos-PEG6

CAS No. 42749-27-9

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