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CS-W001157 4
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1-Naphthohydrazide

  • CAS No. 43038-45-5

  • Cat. No. CS-0149900
  • Molecule weight186.21
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Naphthohydrazide|CS-0149900

Structure of 43038-45-5

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General Information

  • CAS No. 43038-45-5
  • Cat. No. CS-0149900
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀N₂O
  • Molecular Weight 186.21
  • Synonym(s) naphthalene-1-carbohydrazide
  • SMILES NNC(C1=CC=CC2=CC=CC=C21)=O

Description

1-Naphthohydrazide is a bench-stable, electron-rich hydrazide derivative featuring a naphthalene core that enables facile integration into heterocyclic synthesis. This compound serves as a key scaffold for constructing bioactive nitrogen-containing systems, particularly in the development of pharmacophores and ligands for transition metal catalysis.

Application

1-Naphthohydrazide serves as a versatile building block in heterocyclic synthesis, enabling efficient access to quinazoline, pyrazole, and triazole derivatives via condensation and cyclization reactions. Its naphthalene framework imparts enhanced stability and facilitates purification by crystallization, while the hydrazide functionality exhibits reliable reactivity with aldehydes, ketones, and activated esters under mild conditions. Functions effectively in both solution-phase and solid-phase synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   1.4433
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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