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CS-W001157 4
Total: USD 88.00

1-Bromo-4-(trimethylsilyl)but-3-yn-2-one

  • CAS No. 433257-41-1

  • Cat. No. CS-0608567
  • Purity≥96%
  • MDL No.MFCD24464079

*For research and further manufacturing use only, not for direct human use.

1-Bromo-4-(trimethylsilyl)but-3-yn-2-one|CS-0608567

Structure of 433257-41-1

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General Information

  • CAS No. 433257-41-1
  • Cat. No. CS-0608567
  • Purity ≥96%
  • MDL No. MFCD24464079
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₁BrOSi
  • Molecular Weight 219.15
  • Synonym(s) 1-Bromo-4-(trimethylsilyl)-3-butyne-2-one
  • SMILES O=C(C#C[Si](C)(C)C)CBr

Description

1-Bromo-4-(trimethylsilyl)but-3-yn-2-one features a reactive alkyne tethered to a bromo-substituted ketone, enabling efficient copper-catalyzed coupling reactions. The trimethylsilyl group enhances stability and facilitates deprotection under mild conditions, streamlining synthetic access to functionalized alkynes in complex molecule assembly.

Application

1-Bromo-4-(trimethylsilyl)but-3-yn-2-one serves as a versatile building block in transition-metal-catalyzed coupling reactions, enabling efficient access to functionalized alkynyl motifs. The molecule combines a reactive bromide with a silyl-protected alkyne and an α-keto carbonyl group, offering orthogonal reactivity for sequential transformations. Its bench-stable nature and compatibility with palladium- and copper-mediated cross-couplings facilitate streamlined synthesis of complex intermediates for medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS08
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅱ
Hazard Statements : H227-H314-H317-H318-H334-H335
Precautionary Statements : P210-P260-P264-P271-P272-P280-P285-P301+P330+P331-P302+P352-P304+P340-P363-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   1.8312
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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