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CS-W001157 4
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4-(2-Chloroethyl)-1H-pyrazole

  • CAS No. 438475-37-7

  • Cat. No. CS-0452522
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-(2-Chloroethyl)-1H-pyrazole|CS-0452522

Structure of 438475-37-7

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General Information

  • CAS No. 438475-37-7
  • Cat. No. CS-0452522
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇ClN₂
  • Molecular Weight 130.58
  • Synonym(s) None
  • SMILES C(CCl)C1=CNN=C1

Description

4-(2-Chloroethyl)-1H-pyrazole is a reactive heterocyclic compound featuring a chloroethyl side chain that enables efficient alkylation under mild conditions. This moiety integrates readily into bioconjugation workflows and synthetic scaffolds, offering stable linkage formation with nucleophiles. The pyrazole core provides enhanced metabolic stability and favorable solubility in organic media, facilitating use in medicinal chemistry and probe development.

Application

4-(2-Chloroethyl)-1H-pyrazole serves as a versatile bifunctional building block, enabling efficient construction of nitrogen-containing heterocycles and pharmaceutical intermediates. The chloroethyl side chain facilitates nucleophilic substitution reactions, while the pyrazole core provides robust stability and moderate basicity. This compound functions effectively in late-stage functionalization and offers straightforward purification due to its crystalline nature and compatibility with standard chromatographic protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.191
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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