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CS-W001157 4
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4-(2-Chloroethyl)-1H-pyrazole

  • CAS No. 438475-37-7

  • Cat. No. CS-0452522
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-(2-Chloroethyl)-1H-pyrazole|CS-0452522

Structure of 438475-37-7

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Description

4-(2-Chloroethyl)-1H-pyrazole is a reactive heterocyclic compound featuring a chloroethyl side chain that enables efficient alkylation under mild conditions. This moiety integrates readily into bioconjugation workflows and synthetic scaffolds, offering stable linkage formation with nucleophiles. The pyrazole core provides enhanced metabolic stability and favorable solubility in organic media, facilitating use in medicinal chemistry and probe development.

Application

4-(2-Chloroethyl)-1H-pyrazole serves as a versatile bifunctional building block, enabling efficient construction of nitrogen-containing heterocycles and pharmaceutical intermediates. The chloroethyl side chain facilitates nucleophilic substitution reactions, while the pyrazole core provides robust stability and moderate basicity. This compound functions effectively in late-stage functionalization and offers straightforward purification due to its crystalline nature and compatibility with standard chromatographic protocols.

General Information

  • CAS No. 438475-37-7
  • Cat. No. CS-0452522
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇ClN₂
  • Molecular Weight 130.58
  • Synonym(s) None
  • SMILES C(CCl)C1=CNN=C1

Computational Chemistry Data

  • TPSA   28.68
  • LogP   1.191
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

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