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Structure of 4385-77-7
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3-Pyridin-3-yl-benzoic acid features a rigid, planar architecture linking aromatic rings through a direct C–C bond. This configuration imparts enhanced electronic conjugation and facilitates π-stacking interactions. The carboxylic acid group enables facile derivatization for peptide coupling or esterification, while the pyridyl nitrogen offers coordination potential in metal-ligand systems. The molecule exhibits good solubility in polar aprotic solvents and stability under standard bench conditions.
3-Pyridin-3-yl-benzoic acid serves as a versatile building block for constructing biaryl and heterobiaryl scaffolds in medicinal chemistry. Its dual aromatic functionality enables efficient coupling reactions, including Suzuki-Miyaura and Ullmann-type processes, under standard conditions. The carboxylic acid group facilitates direct derivatization or activation for amide bond formation, while the pyridyl nitrogen offers coordination potential. Bench-stable and readily purified by recrystallization, it functions effectively in multistep syntheses targeting kinase inhibitors and other bioactive compounds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: