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CS-W001157 4
Total: USD 88.00

2-Chloro-5-fluorobenzeneboronic acid

  • CAS No. 444666-39-1

  • Cat. No. CS-0043740
  • Purity≥98%
  • MDL No.MFCD06656272
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-fluorobenzeneboronic acid|CS-0043740

Structure of 444666-39-1

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Description

2-Chloro-5-fluorobenzeneboronic acid features a strategically positioned boronic acid group on a fluorinated, chlorinated aromatic scaffold. This combination enhances stability and reactivity in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under standard conditions. The electron-withdrawing halogens modulate electronic properties for predictable transformation outcomes.

Application

2-Chloro-5-fluorobenzeneboronic acid serves as a versatile building block in palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation under standard Suzuki-Miyaura conditions. Its dual halogen functionality offers orthogonal reactivity for sequential transformations, while the boronic acid group provides excellent bench stability and compatibility with diverse functional groups. This compound facilitates the construction of complex aryl architectures commonly found in pharmaceutical intermediates and advanced materials.

General Information

  • CAS No. 444666-39-1
  • Cat. No. CS-0043740
  • Purity ≥98%
  • MDL No. MFCD06656272
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅BClFO₂
  • Molecular Weight None
  • Synonym(s) Boronic acid, B-(2-chloro-5-fluorophenyl)-
  • SMILES OB(C1=CC(F)=CC=C1Cl)O

Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.1589
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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