4-Bromo-1-chloro-2-(trifluoromethyl)benzene

Name: 4-Bromo-1-chloro-2-(trifluoromethyl)benzene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 445-01-2
Cat. No. CS-W009455
Purity≥98%
MDL No.MFCD00000601

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Bromo-1-chloro-2-(trifluoromethyl)benzene|CS-W009455

Structure of 445-01-2

Size

Price

Quantity

* Please select Quantity before adding items.

Description

4-Bromo-1-chloro-2-(trifluoromethyl)benzene is a trifluoromethyl-substituted aryl halide featuring orthogonal bromo and chloro handles for sequential functionalization. The electron-deficient aromatic core enables efficient cross-coupling reactions, while the trifluoromethyl group enhances metabolic stability and lipophilicity. This compound serves as a valuable intermediate in medicinal chemistry and materials synthesis.

Application

4-Bromo-1-chloro-2-(trifluoromethyl)benzene serves as a versatile building block in cross-coupling reactions, enabling efficient construction of complex aryl architectures. The ortho-chloro and bromo substituents provide complementary reactivity for sequential functionalization, while the trifluoromethyl group enhances metabolic stability and modulates electronic properties. Bench-stable and compatible with standard Pd-catalyzed coupling protocols, it facilitates the synthesis of biologically relevant scaffolds and advanced intermediates in medicinal chemistry and materials science.

General Information

CAS No. 445-01-2
Cat. No. CS-W009455
Purity ≥98%
MDL No. MFCD00000601
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₃BrClF₃
Molecular Weight 259.45
Synonym(s) 5-Bromo-2-chloro-α,α,α-trifluorotoluene
SMILES FC(C1=CC(Br)=CC=C1Cl)(F)F

Computational Chemistry Data

TPSA 0
LogP 4.1213
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H227-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

445-01-2 sigma445-01-2 manufacturer445-01-2 price445-01-2 structure445-01-2 SDSbuy 445-01-2445-01-2 supplier445-01-2 uses445-01-2 molecular weightprice of 445-01-2445-01-2 chemical name formula of 445-01-2

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

4-Bromo-1-chloro-2-(trifluoromethyl)benzene

CAS No. 445-01-2

Recommended Products