1-Bromo-4-fluoro-2-nitrobenzene

Name: 1-Bromo-4-fluoro-2-nitrobenzene
Brand: ChemScene
Availability: InStock
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CAS No. 446-09-3
Cat. No. CS-W002267
Purity≥98%
MDL No.MFCD00055530

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-Bromo-4-fluoro-2-nitrobenzene|CS-W002267

Structure of 446-09-3

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Description

1-Bromo-4-fluoro-2-nitrobenzene features a trifunctional aryl scaffold enabling sequential cross-coupling and nucleophilic substitution. The electron-deficient ring enhances reactivity in palladium-catalyzed processes, while the bromo and fluoro groups offer orthogonal functionalization handles. This bench-stable compound integrates seamlessly into complex molecule assembly workflows.

Application

1-Bromo-4-fluoro-2-nitrobenzene serves as a versatile building block in cross-coupling and nucleophilic aromatic substitution reactions. The ortho-difunctionalized aryl scaffold enables sequential functionalization, with the bromide facilitating palladium-catalyzed couplings and the fluoride enabling selective displacement under mild conditions. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for constructing complex heterocycles and pharmaceutical intermediates.

General Information

CAS No. 446-09-3
Cat. No. CS-W002267
Purity ≥98%
MDL No. MFCD00055530
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃BrFNO₂
Molecular Weight 220.00
Synonym(s) 2-Bromo-5-fluoronitrobenzene
SMILES Fc1ccc(c(c1)[N+](=O)[O-])Br

Computational Chemistry Data

TPSA 43.14
LogP 2.4964
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS06
Signal Word : Danger	UN#: 2811
Class : 6.1	Packing Group : Ⅲ
Hazard Statements : H302+H312-H315-H319-H331-H335
Precautionary Statements : P264-P270-P330-P405-P501

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Other Classifications

Building Blocks Functional Group Nitro compounds

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-Bromo-4-fluoro-2-nitrobenzene

CAS No. 446-09-3

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