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Structure of 446-36-6
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5-Fluoro-2-nitrophenol features a fluorine atom at the meta position relative to a nitro group on a phenolic scaffold, delivering enhanced electron-withdrawal and improved metabolic stability. This configuration enables efficient coupling in cross-coupling reactions and facilitates selective functionalization in pharmaceutical intermediates.
5-Fluoro-2-nitrophenol serves as a versatile building block in synthetic organic chemistry, enabling the construction of substituted heterocycles and pharmaceutical intermediates. Its ortho-dinitro substitution pattern facilitates selective functionalization, while the fluorine atom enhances metabolic stability and modulates electronic properties. The compound exhibits good bench stability and is compatible with standard coupling reactions, purification via recrystallization, and further transformations under mild conditions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: