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Structure of 446-38-8
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3-Fluoro-4-nitroanisole features a strategically positioned fluorine atom and a nitro group on an aromatic ring, enabling selective coupling reactions in medicinal chemistry. This electron-deficient aryl scaffold integrates readily into complex molecular architectures under standard conditions.
3-Fluoro-4-nitroanisole serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the aromatic ring via palladium-catalyzed cross-coupling. The ortho-fluoro and para-nitro groups provide orthogonal reactivity for sequential transformations, while the methoxy group enhances solubility and modulates electronic properties. Bench-stable and readily purified by flash chromatography, it facilitates efficient synthesis of substituted heterocycles and complex scaffolds relevant to API development.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H314-H335
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: