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CS-W001157 4
Total: USD 88.00

2,3-Dimethoxytoluene

  • CAS No. 4463-33-6

  • Cat. No. CS-M3411
  • Purity≥98%
  • MDL No.MFCD00008379

*For research and further manufacturing use only, not for direct human use.

2,3-Dimethoxytoluene|CS-M3411

Structure of 4463-33-6

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General Information

  • CAS No. 4463-33-6
  • Cat. No. CS-M3411
  • Purity ≥98%
  • MDL No. MFCD00008379
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂O₂
  • Molecular Weight 152.19
  • Synonym(s) 1,2-Dimethoxy-3-methylbenzene; 2,3-Dimethoxytoluene; 3-Methyl-1,2-dimethoxybenzene; 3-Methylcatechol dimethyl ether; 3-Methylveratrole; NSC 72350; o-Homoveratrole; 1,2-Dimethoxy-3-methyl-benzene
  • SMILES CC1=CC=CC(OC)=C1OC

Description

2,3-Dimethoxytoluene has been used to prepare 6,7-dimethoxy-4-hydroxyisochroman-3-one.

Application

2,3-Dimethoxytoluene serves as a versatile building block in synthetic organic chemistry, offering predictable reactivity in electrophilic aromatic substitution and transition-metal-catalyzed coupling reactions. Its ortho-dimethoxy pattern enhances electron density at the aromatic ring while providing orthogonal protection for further functionalization. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis of complex heterocycles and pharmaceutical intermediates.

Synthesis

  • Route1

    References

    • Xing, Lixin; Wang, Xinyan; Cheng, Chuanjie; Zhu, Rui; Liu, Bo; Hu, Yuefei Tetrahedron, 2007 , vol. 63, # 38 p. 9382 - 9386
  • Route2
    • 1,2-Dimethoxybenzene Methoxamine  Impurity|CS-0229041
      91-16-7
    • null|null
      74-88-4
    • ~82%
    • In-stock
      2,3-Dimethoxytoluene|CS-M3411
      4463-33-6

    References

    • Werle, Susen; Fey, Thorsten; Neudoerfl, Joerg M.; Schmalz, Hans-Guenther Organic Letters, 2007 , vol. 9, # 18 p. 3555 - 3558
  • Route3
    • null|null
      77-78-1
    • In-stock
      3-Methylcatechol|CS-W013531
      488-17-5
    • ~91%
    • In-stock
      2,3-Dimethoxytoluene|CS-M3411
      4463-33-6

    References

    • Surendra, Karavadhi; Rajendar, Goreti; Corey Journal of the American Chemical Society, 2014 , vol. 136, # 2 p. 642 - 645

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.01222
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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