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CS-W001157 4
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4-Nitro-2(1H)-pyridinone

  • CAS No. 4487-51-8

  • Cat. No. CS-0084619
  • Purity≥97%
  • MDL No.MFCD04114149

*For research and further manufacturing use only, not for direct human use.

4-Nitro-2(1H)-pyridinone|CS-0084619

Structure of 4487-51-8

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General Information

  • CAS No. 4487-51-8
  • Cat. No. CS-0084619
  • Purity ≥97%
  • MDL No. MFCD04114149
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄N₂O₃
  • Molecular Weight 140.10
  • Synonym(s) 4-Nitropyridin-2-ol
  • SMILES O=C1C=C([N+]([O-])=O)C=CN1

Description

4-Nitro-2(1H)-pyridinone is a bench-stable, electron-deficient heterocycle featuring a strategically positioned nitro group that enhances reactivity in nucleophilic substitution and transition metal-catalyzed coupling processes. This nitrogen-rich scaffold integrates readily into bioactive molecules and functional materials, offering predictable regiochemistry and compatibility with diverse reaction conditions.

Application

4-Nitro-2(1H)-pyridinone serves as a versatile building block in medicinal and synthetic chemistry, enabling efficient access to nitrogen-rich heterocyclic scaffolds. Its dual functionality—electron-deficient pyridinone core and readily reducible nitro group—facilitates diverse transformations, including palladium-catalyzed couplings and reductive functionalization. The compound exhibits good bench stability and compatibility with common protecting group strategies, supporting its use in multi-step synthesis of API intermediates and targeted libraries.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   76
  • LogP   0.2831
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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