Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4-Fluoro-2-methoxybenzaldehyde

  • CAS No. 450-83-9

  • Cat. No. CS-W018054
  • Molecule weight154.14
  • Purity≥98%
  • MDL No.MFCD00143318

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-2-methoxybenzaldehyde|CS-W018054

Structure of 450-83-9

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 450-83-9
  • Cat. No. CS-W018054
  • Purity ≥98%
  • MDL No. MFCD00143318
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₂
  • Molecular Weight 154.14
  • Synonym(s) 2-METHOXY-4-FLUOROBENZALDEHYDE; 4-Fluoro-2-methoxybenzaldehyde
  • SMILES O=CC1=CC=C(F)C=C1OC

Description

4-Fluoro-2-methoxybenzaldehyde features a fluorine atom at the para position and a methoxy group at the ortho position relative to the aldehyde, delivering enhanced electron withdrawal and steric influence. This combination enables selective reactivity in cross-coupling and condensation reactions, particularly valuable in synthesizing bioactive heterocycles and pharmaceutical intermediates under standard conditions.

Application

4-Fluoro-2-methoxybenzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, offering a strategically positioned aldehyde group for reductive amination, Grignard addition, or Wittig reactions. The ortho-methoxy and para-fluoro substituents provide enhanced electronic tuning and metabolic stability, while the compound exhibits excellent bench stability and facilitates straightforward purification via flash chromatography.

Synthesis

  • Route1
    • In-stock
      4-Fluorosalicylaldehyde|CS-W008001
      348-28-7
    • null|null
      74-88-4
    • ~84%
    • In-stock
      4-Fluoro-2-methoxybenzaldehyde|CS-W018054
      450-83-9

    References

    • St. Jean Jr., David J.; Poon, Steve F.; Schwarzbach, Jamie L. Organic Letters, 2007 , vol. 9, # 23 p. 4893 - 4896
  • Route2
    • In-stock
      4-Fluorosalicylaldehyde|CS-W008001
      348-28-7
    • null|null
      74-88-4
    • ~%
    • null|null
      303043-87-0
    • In-stock
      4-Fluoro-2-methoxybenzaldehyde|CS-W018054
      450-83-9

    References

    • Hoffmann-La Roche Inc. Patent: US6376672 B1, 2002 ;
  • Route3

    References

    • Hodgson; Nixon Journal of the Chemical Society, 1929 , p. 1639

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   26.3
  • LogP   1.6468
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 4-Fluoro-2-methoxybenzaldehyde sigma4-Fluoro-2-methoxybenzaldehyde manufacturer4-Fluoro-2-methoxybenzaldehyde price4-Fluoro-2-methoxybenzaldehyde structure4-Fluoro-2-methoxybenzaldehyde SDSbuy 4-Fluoro-2-methoxybenzaldehyde4-Fluoro-2-methoxybenzaldehyde supplier4-Fluoro-2-methoxybenzaldehyde uses4-Fluoro-2-methoxybenzaldehyde molecular weightprice of 4-Fluoro-2-methoxybenzaldehyde4-Fluoro-2-methoxybenzaldehyde chemical name formula of 4-Fluoro-2-methoxybenzaldehyde
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label