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Structure of 452-68-6
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1-Fluoro-4-iodo-2-methylbenzene features a strategically positioned fluorine and iodine on a methyl-substituted benzene ring, enabling direct functionalization in cross-coupling reactions. The electron-withdrawing fluorine enhances reactivity at the adjacent carbon, while the iodine serves as a high-efficiency coupling handle. This compound exhibits bench-stable handling characteristics and integrates readily into complex molecular architectures under standard conditions.
1-Fluoro-4-iodo-2-methylbenzene serves as a versatile building block in cross-coupling chemistry, enabling efficient Suzuki, Stille, and Negishi reactions due to its orthogonal halogen reactivity. The fluorine substituent enhances metabolic stability and modulates electronic properties, while the iodine group facilitates high-yielding transformations under mild conditions. Bench-stable and readily purified by distillation, it functions effectively in the synthesis of substituted biaryls and functionalized heterocycles relevant to pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: