Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

4-Fluoro-3-methylphenol

  • CAS No. 452-70-0

  • Cat. No. CS-W002208
  • Purity≥95%
  • MDL No.MFCD00042296

*For research and further manufacturing use only, not for direct human use.

4-Fluoro-3-methylphenol|CS-W002208

Structure of 452-70-0

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 452-70-0
  • Cat. No. CS-W002208
  • Purity ≥95%
  • MDL No. MFCD00042296
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FO
  • Molecular Weight 126.13
  • Synonym(s) Fluoromethylphenol4
  • SMILES Oc1ccc(c(c1)C)F

Description

4-Fluoro-3-methylphenol was used to detect the aromatic metabolites in methanogenic m-cresol-degrading consortium. It was also used in the preparation of 8-fluoronaphthoquinone via Friedel Crafts acylation reaction with maleic anhydride.

Application

4-Fluoro-3-methylphenol serves as a valuable building block in medicinal chemistry, enabling the construction of fluorinated aromatic scaffolds with enhanced metabolic stability. Its ortho-substituted phenolic functionality facilitates direct electrophilic substitution and Suzuki-Miyaura coupling reactions, while the methyl group provides a handle for oxidation or functionalization. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis workflows in API development.

Synthesis

  • Route1

    References

    • Samant, Bhupesh S.; Bhagwat, Sunil S. Applied Catalysis A: General, 2011 , vol. 394, # 1-2 p. 191 - 194
  • Route2
    • null|null
      108-39-4
    • ~57%
    • In-stock
      4-Fluoro-3-methylphenol|CS-W002208
      452-70-0
    • In-stock
      2-Fluoro-5-methylphenol|CS-W008056
      63762-79-8

    References

    • Singh, Sukhjinder; DesMarteau, Darryl D.; Zuberi, Sharique S.; Witz, Michael; Huang, Hsu-Nan Journal of the American Chemical Society, 1987 , vol. 109, # 23 p. 7194 - 7196
  • Route3
    • 4-(tert-Butyl)-3-methylphenol|CS-1013032
      2219-72-9
    • ~37%
    • In-stock
      4-Fluoro-3-methylphenol|CS-W002208
      452-70-0

    References

    • Gao, Zhanghua; Lim, Yee Hwee; Tredwell, Matthew; Li, Lei; Verhoog, Stefan; Hopkinson, Matthew; Kaluza, Wojciech; Collier, Thomas Lee; Passchier, Jan; Huiban, Mickael; Gouverneur, Veronique Angewandte Chemie - International Edition, 2012 , vol. 51, # 27 p. 6733 - 6737

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.83972
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 4-Fluoro-3-methylphenol sigma4-Fluoro-3-methylphenol manufacturer4-Fluoro-3-methylphenol price4-Fluoro-3-methylphenol structure4-Fluoro-3-methylphenol SDSbuy 4-Fluoro-3-methylphenol4-Fluoro-3-methylphenol supplier4-Fluoro-3-methylphenol uses4-Fluoro-3-methylphenol molecular weightprice of 4-Fluoro-3-methylphenol4-Fluoro-3-methylphenol chemical name formula of 4-Fluoro-3-methylphenol
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label