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Structure of 452-70-0
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4-Fluoro-3-methylphenol was used to detect the aromatic metabolites in methanogenic m-cresol-degrading consortium. It was also used in the preparation of 8-fluoronaphthoquinone via Friedel Crafts acylation reaction with maleic anhydride.
4-Fluoro-3-methylphenol serves as a valuable building block in medicinal chemistry, enabling the construction of fluorinated aromatic scaffolds with enhanced metabolic stability. Its ortho-substituted phenolic functionality facilitates direct electrophilic substitution and Suzuki-Miyaura coupling reactions, while the methyl group provides a handle for oxidation or functionalization. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for iterative synthesis workflows in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: