2-Fluoro-4-methylphenol

Name: 2-Fluoro-4-methylphenol
Brand: ChemScene
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CAS No. 452-81-3
Cat. No. CS-W003002
Purity≥97%
MDL No.MFCD03094332

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 452-81-3

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Description

2-Fluoro-4-methylphenol features a fluorine atom at the ortho position and a methyl group at the para position relative to the hydroxyl group, creating a uniquely activated aromatic system. This substitution pattern enhances electrophilic reactivity while maintaining bench stability, enabling direct incorporation into pharmaceutical intermediates and agrochemical scaffolds via C–H functionalization or coupling reactions.

Application

2-Fluoro-4-methylphenol serves as a valuable building block in medicinal chemistry, enabling the construction of fluorinated aromatic scaffolds prevalent in pharmaceuticals. Its ortho-fluoro substitution facilitates electrophilic aromatic substitution and Suzuki-Miyaura coupling reactions, while the phenolic hydroxyl group offers direct derivatization potential. The methyl group provides steric and electronic modulation, enhancing metabolic stability. Bench-stable and readily purified by recrystallization, it functions effectively in multi-step syntheses requiring functional group compatibility and predictable reactivity.

General Information

CAS No. 452-81-3
Cat. No. CS-W003002
Purity ≥97%
MDL No. MFCD03094332
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₇FO
Molecular Weight 126.13
Synonym(s) 3-Fluoro-4-hydroxytoluene, 2-Fluoro-p-cresol
SMILES Cc1ccc(c(c1)F)O

Computational Chemistry Data

TPSA 20.23
LogP 1.83972
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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2-Fluoro-4-methylphenol

CAS No. 452-81-3

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