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CS-W001157 4
Total: USD 88.00

5-Fluoro-2-methylphenol

  • CAS No. 452-85-7

  • Cat. No. CS-W011163
  • Purity≥98%
  • MDL No.MFCD00673009
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-methylphenol|CS-W011163

Structure of 452-85-7

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Description

5-Fluoro-2-methylphenol is a fluorinated aromatic phenol featuring ortho-methyl and meta-fluoro substituents on the benzene ring. This configuration imparts enhanced electron-withdrawing character and improved metabolic stability, making it valuable in pharmaceutical intermediates and agrochemical synthesis. The compound exhibits favorable solubility in organic solvents and stability under standard bench conditions.

Application

5-Fluoro-2-methylphenol serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via electrophilic substitution and coupling reactions. Its ortho-methyl group enhances regioselectivity in downstream functionalization, while the phenolic hydroxyl facilitates derivatization through etherification or esterification. The molecule exhibits good bench stability and is compatible with standard purification methods, making it well-suited for use in iterative synthetic sequences targeting bioactive heterocycles and API intermediates.

General Information

  • CAS No. 452-85-7
  • Cat. No. CS-W011163
  • Purity ≥98%
  • MDL No. MFCD00673009
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇FO
  • Molecular Weight 126.13
  • Synonym(s) Phenol, 5-fluoro-2-methyl-
  • SMILES C1=C(F)C=CC(=C1O)C

Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.83972
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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