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Structure of 452-85-7
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5-Fluoro-2-methylphenol is a fluorinated aromatic phenol featuring ortho-methyl and meta-fluoro substituents on the benzene ring. This configuration imparts enhanced electron-withdrawing character and improved metabolic stability, making it valuable in pharmaceutical intermediates and agrochemical synthesis. The compound exhibits favorable solubility in organic solvents and stability under standard bench conditions.
5-Fluoro-2-methylphenol serves as a valuable building block in medicinal chemistry, enabling the synthesis of fluorinated aromatic scaffolds via electrophilic substitution and coupling reactions. Its ortho-methyl group enhances regioselectivity in downstream functionalization, while the phenolic hydroxyl facilitates derivatization through etherification or esterification. The molecule exhibits good bench stability and is compatible with standard purification methods, making it well-suited for use in iterative synthetic sequences targeting bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3265
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: