Lot numbers can be found on the outside label of a product:
2-Fluoropyridine-3-boronic acid pinacol ester
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CAS No. 452972-14-4
- Cat. No. CS-W003352
- Purity≥98%
- MDL No.MFCD06798245
*For research and further manufacturing use only, not for direct human use.
Structure of 452972-14-4
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General Information
- CAS No. 452972-14-4
- Cat. No. CS-W003352
- Purity ≥98%
- MDL No. MFCD06798245
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₁H₁₅BFNO₂
- Molecular Weight 223.05
- Synonym(s) pyridine, 2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
- SMILES CC1(C)OB(OC1(C)C)c1cccnc1F
Description
2-Fluoropyridine-3-boronic acid pinacol ester offers a stable, bench-ready platform for palladium-catalyzed cross-coupling reactions. The boronate moiety integrates seamlessly into complex heterocyclic architectures, enabling efficient C–C bond formation under mild conditions. This moisture-tolerant reagent simplifies handling in synthetic workflows involving fluorinated pyridines.
Application
2-Fluoropyridine-3-boronic acid pinacol ester serves as a stable, bench-ready building block for Suzuki-Miyaura cross-coupling reactions. Its fluorinated pyridine core enables efficient late-stage functionalization in medicinal chemistry and materials synthesis. The pinacol ester enhances solubility and stability while maintaining high reactivity under standard catalytic conditions. Functions effectively in C–C bond formation with aryl and heteroaryl halides, offering predictable regiochemistry and broad functional group tolerance.
Synthesis
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Route1
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In-stock
76-09-5 -
372-48-5 -
5419-55-6
- ~34%
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In-stock
452972-14-4
References
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CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; LI, Jijun; ZHU, Yan; HU, Yuandong; WANG, Huting; WANG, Zhe; WANG, Zanping; WEI, Yongheng; SUN, Yinghui; WU, Qiong; ZHANG, Hui; PENG, Yong; KONG, Fansheng; SUN, Ying; LUO, Hong; HAN, Yongxin Patent: WO2013/71865 A1, 2013 ; Location in patent: Page/Page column 27 ;
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Route2
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In-stock
76-09-5
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372-48-5
- ~56%
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In-stock
452972-14-4
References
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Bouillon, Alexandre; Lancelot, Jean-Charles; Collot, Valerie; Bovy, Philippe R.; Rault, Sylvain Tetrahedron, 2002 , vol. 58, # 17 p. 3323 - 3328
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References
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Watson, Charlotte G.; Aggarwal, Varinder K. Organic Letters, 2013 , vol. 15, # 6 p. 1346 - 1349
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 31.35
- LogP 1.5199
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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