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Structure of 455-37-8
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3-Fluorobenzamide serves as a key aryl amide building block in medicinal chemistry, offering enhanced metabolic stability and improved membrane permeability. The meta-fluoro substitution imparts favorable electronic properties for target engagement, while the amide functionality enables direct incorporation into peptide-like scaffolds or coupling reactions under standard conditions.
3-Fluorobenzamide serves as a versatile building block in medicinal chemistry, enabling direct incorporation of fluorinated aromatic scaffolds into target molecules. Its amide functionality offers enhanced metabolic stability and favorable polarity profiles, while the ortho-fluoro substituent facilitates downstream functionalization via nucleophilic aromatic substitution or transition-metal-catalyzed coupling. Bench-stable and readily purified by crystallization, it functions effectively in standard peptide coupling and heterocycle synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: