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Structure of 457051-15-9
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4-Bromo-2-fluoro-6-methoxybenzonitrile features a trifunctional aromatic core with bromine, fluorine, and methoxy groups positioned ortho to each other, enabling precise C–C coupling and cross-coupling transformations. The nitrile group provides a high-affinity handle for nucleophilic additions and downstream functionalization. This electron-deficient scaffold exhibits excellent stability under standard reaction conditions and facilitates the synthesis of complex heterocycles and bioactive molecules.
4-Bromo-2-fluoro-6-methoxybenzonitrile serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its compatible bromo and nitrile functionalities. The fluorine and methoxy groups provide orthogonal reactivity and modulate electronic properties, enhancing metabolic stability. Its bench-stable nature and straightforward purification facilitate integration into multi-step synthetic sequences for heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: