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CS-W001157 4
Total: USD 88.00

2-Chloropyridine-4-boronic acid

  • CAS No. 458532-96-2

  • Cat. No. CS-D1048
  • Purity≥98%
  • MDL No.MFCD03788416

*For research and further manufacturing use only, not for direct human use.

2-Chloropyridine-4-boronic acid|CS-D1048

Structure of 458532-96-2

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General Information

  • CAS No. 458532-96-2
  • Cat. No. CS-D1048
  • Purity ≥98%
  • MDL No. MFCD03788416
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅BClNO₂
  • Molecular Weight 157.37
  • Synonym(s) None
  • SMILES ClC1=NC=CC(B(O)O)=C1

Application

2-Chloropyridine-4-boronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The boronic acid group exhibits excellent bench stability and compatibility with diverse functional groups, while the ortho-chloropyridine moiety provides a handle for subsequent functionalization via palladium-catalyzed transformations. Its predictable reactivity and ease of purification make it a practical choice for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Tetrahedron, , vol. 58, # 22 p. 4369 - 4373

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   -0.5852
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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