Lot numbers can be found on the outside label of a product:
7-Fluoro-3,4-dihydroquinolin-2(1H)-one
-
CAS No. 4590-52-7
- Cat. No. CS-0043835
- Purity≥97%
- MDL No.None
*For research and further manufacturing use only, not for direct human use.
Structure of 4590-52-7
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 4590-52-7
- Cat. No. CS-0043835
- Purity ≥97%
- MDL No. None
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₉H₈FNO
- Molecular Weight 165.16
- Synonym(s) None
- SMILES O=C1NC2=C(C=CC(F)=C2)CC1
Description
7-Fluoro-3,4-dihydroquinolin-2(1H)-one features a fluorinated quinolinone core with enhanced electron-withdrawing character due to the para-fluorine substitution. This scaffold integrates readily into medicinal chemistry libraries, offering improved metabolic stability and membrane permeability. The saturated ring system provides conformational rigidity beneficial for target binding.
Application
7-Fluoro-3,4-dihydroquinolin-2(1H)-one serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling efficient access to bioactive molecules through established functionalization at the 2-position and C3–C4 ring system. Its fluorinated aromatic core enhances metabolic stability and modulates electronic properties, while the lactam functionality supports diverse transformations including nucleophilic substitution and transition-metal-catalyzed coupling. Bench-stable and amenable to purification via standard chromatography, it functions as a reliable building block for targeted synthesis of pharmaceutical intermediates and CNS-active compounds.
Synthesis
-
Route1
-
In-stock
100638-26-4 - ~62%
-
In-stock
4590-52-7
References
-
BIOENERGENIX; MCCALL, John, M.; ROMERO, Donna, L. Patent: WO2012/94462 A2, 2012 ; Location in patent: Page/Page column 86 ; WO 2012/094462 A2
-
-
Route2
-
In-stock
100638-26-4
- ~%
-
116434-95-8 -
In-stock
4590-52-7
References
-
F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; HORNSPERGER, Benoit; KNUST, Henner; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; ZHOU, Mingwei Patent: WO2013/37779 A1, 2013 ; Location in patent: Page/Page column 231 ;
-
-
Route3
-
79-06-1 -
In-stock
313545-72-1 - ~93%
-
In-stock
4590-52-7
References
-
Zhang, Lei; Sonaglia, Lorenzo; Stacey, Jason; Lautens, Mark Organic Letters, 2013 , vol. 15, # 9 p. 2128 - 2131
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302-H315-H319-H335
|
|
|
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
|
|
Quality Control
Computational Chemistry Data
- TPSA 29.1
- LogP 1.7104
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 0
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 7-Fluoro-3,4-dihydroquinolin-2(1H)-one sigma7-Fluoro-3,4-dihydroquinolin-2(1H)-one manufacturer7-Fluoro-3,4-dihydroquinolin-2(1H)-one price7-Fluoro-3,4-dihydroquinolin-2(1H)-one structure7-Fluoro-3,4-dihydroquinolin-2(1H)-one SDSbuy 7-Fluoro-3,4-dihydroquinolin-2(1H)-one7-Fluoro-3,4-dihydroquinolin-2(1H)-one supplier7-Fluoro-3,4-dihydroquinolin-2(1H)-one uses7-Fluoro-3,4-dihydroquinolin-2(1H)-one molecular weightprice of 7-Fluoro-3,4-dihydroquinolin-2(1H)-one7-Fluoro-3,4-dihydroquinolin-2(1H)-one chemical name formula of 7-Fluoro-3,4-dihydroquinolin-2(1H)-one