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(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-bromo-1H-indol-3-yl)propanoic acid

  • CAS No. 460751-66-0

  • Cat. No. CS-0452669
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-bromo-1H-indol-3-yl)propanoic acid|CS-0452669

Structure of 460751-66-0

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General Information

  • CAS No. 460751-66-0
  • Cat. No. CS-0452669
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₆H₂₁BrN₂O₄
  • Molecular Weight 505.36
  • Synonym(s) Fmoc-L-5-BromoTryptophan
  • SMILES C1(C2=C(C=CC=C2)C3=C1C=CC=C3)COC(N[C@@H](CC4=CNC5=CC=C(C=C54)Br)C(O)=O)=O

Description

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-bromo-1H-indol-3-yl)propanoic acid is a bench-stable, moisture-tolerant chiral building block featuring a protected amino acid backbone with a sterically hindered fluorenylmethoxycarbonyl (Fmoc) group. This indole-containing derivative integrates readily into peptide synthesis workflows, delivering high coupling efficiency and enabling the incorporation of biologically active indolic motifs into complex sequences.

Application

(S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-bromo-1H-indol-3-yl)propanoic acid serves as a key chiral building block for the synthesis of biologically active peptides and peptidomimetics. The fluorenylmethoxycarbonyl (Fmoc) group provides excellent stability and ease of removal under mild basic conditions, while the 5-bromoindole moiety offers a versatile handle for further functionalization via cross-coupling reactions. This compound exhibits high bench stability and facilitates efficient purification, making it well-suited for solid-phase peptide synthesis and medicinal chemistry applications.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   91.42
  • LogP   5.4648
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   6

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