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CS-W001157 4
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3-Fluoropropan-1-ol

  • CAS No. 462-43-1

  • Cat. No. CS-0170820
  • Purity≥98%
  • MDL No.MFCD00039548

*For research and further manufacturing use only, not for direct human use.

3-Fluoropropan-1-ol|CS-0170820

Structure of 462-43-1

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General Information

  • CAS No. 462-43-1
  • Cat. No. CS-0170820
  • Purity ≥98%
  • MDL No. MFCD00039548
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₇FO
  • Molecular Weight 78.09
  • Synonym(s) Propanol, 3-fluoro-
  • SMILES C(CF)CO

Description

3-Fluoropropan-1-ol is a fluorinated aliphatic alcohol featuring a terminal hydroxyl group and a strategically positioned fluorine atom at the γ-position. This combination imparts enhanced polarity and metabolic stability, making it valuable for synthesizing bioactive molecules and specialty polymers under standard conditions.

Application

3-Fluoropropan-1-ol serves as a versatile fluorinated building block for medicinal chemistry and agrochemical synthesis. Its primary alcohol functionality enables straightforward derivatization, while the β-fluoro substitution imparts enhanced metabolic stability and modulates electronic properties. The compound exhibits good bench stability and compatibility with standard functional group manipulations, facilitating incorporation into complex molecular architectures via etherification, esterification, or coupling reactions.

Synthesis

  • Route1
    • null|null
      627-30-5
    • ~54%
    • In-stock
      3-Fluoropropan-1-ol|CS-0170820
      462-43-1

    References

    • Tian, Haibin; Vogel, Rebecca; Amici, Louis; Tamagnan, Gilles; Baldwin, Ronald M. Journal of Labelled Compounds and Radiopharmaceuticals, 2006 , vol. 49, # 14 p. 1247 - 1258
  • Route2
    • null|null
      71742-12-6
    • ~36%
    • In-stock
      3-Fluoropropan-1-ol|CS-0170820
      462-43-1

    References

    • Katritzky, Alan R.; Patel, Ranjan C. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2901 - 2903
  • Route3
    • null|null
      115952-64-2
    • ~%
    • In-stock
      3-Fluoropropan-1-ol|CS-0170820
      462-43-1

    References

    • Van Oosten, Erik M.; Wilson, Alan A.; Mamo, David C.; Pollock, Bruce G.; Mulsant, Benoit H.; Houle, Sylvain; Vasdev, Neil Canadian Journal of Chemistry, 2010 , vol. 88, # 12 p. 1222 - 1232

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H315-H319
Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P302+P352-P362-P370+P378-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   0.3383
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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