Fmoc-D-Hyp(tBu)-OH

Name: Fmoc-D-Hyp(tBu)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 464193-92-8
Cat. No. CS-0053412
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Description

Fmoc-D-Hyp(tBu)-OH is a bench-stable, moisture-tolerant amino acid derivative featuring a tert-butyl-protected hydroxyproline residue. This configuration enhances solubility and stability during solid-phase peptide synthesis, enabling efficient incorporation of D-Hyp into bioactive peptide sequences.

Application

Fmoc-D-Hyp(tBu)-OH serves as a key building block in the synthesis of peptide libraries and bioactive oligomers, leveraging the well-established stability and orthogonal protection of the Fmoc group. The D-Hyp(tBu) moiety provides a conformationally restricted proline analog with enhanced rigidity, facilitating the incorporation of type I collagen-mimetic structures. Its t-butyl-protected hydroxyl group enables selective derivatization and is compatible with standard solid-phase peptide synthesis protocols.

General Information

CAS No. 464193-92-8
Cat. No. CS-0053412
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₇NO₅
Molecular Weight 409.47
Synonym(s) Fmoc-O-tert-butyl-D-4-hydroxyproline
SMILES CC(C)(C)O[C@H]1C[C@H](N(C1)C(=O)OCC1C2=CC=CC=C2C2=C1C=CC=C2)C(O)=O

Computational Chemistry Data

TPSA 76.07
LogP 4.2781
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 4

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Proline and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-D-Hyp(tBu)-OH

CAS No. 464193-92-8

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