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CS-W001157 4
Total: USD 88.00

Hexane-1,6-diyldiphosphonic acid

  • CAS No. 4721-22-6

  • Cat. No. CS-0115747
  • Molecule weight246.14
  • Purity≥95%
  • MDL No.MFCD01630742

*For research and further manufacturing use only, not for direct human use.

Hexane-1,6-diyldiphosphonic acid|CS-0115747

Structure of 4721-22-6

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General Information

  • CAS No. 4721-22-6
  • Cat. No. CS-0115747
  • Purity ≥95%
  • MDL No. MFCD01630742
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₆O₆P₂
  • Molecular Weight 246.14
  • Synonym(s) 1,6-Hexanebisphosphonic acid
  • SMILES O=P(O)(O)CCCCCCP(O)(O)=O

Description

Puromycin aminonucleoside is the aminonucleoside portion of the antibiotic puromycin. It is useful in nephrology research, like studies of focal and segmental glomerulosclerosis and in the induction of nephrosis in rats. The excretion of sodium and nitrite (NOx) metabolites in rats with puromycin aminonucleoside-induced nephrotic syndrome are studied. Puromycin aminonucleoside-induced nephrosis in rats has been studied with respect to the production of reactive oxygen species during the acute phase. Puromycin aminonucleoside is used to probe endothelial glycosaminoglycan synthesis in cultured glomerular endothelial cells and their relation to cell permeability.Puromycin aminonucleoside has been used: as a selection marker for the infected cells for the transfection of lentivirusas a component of fresh medium for transfection and infection assaysto subcutaneously induce puromycin aminonucleoside nephrosis to investigate the mRNA and protein levels of nephrin and podocin before the onset of proteinuria

Synthesis

  • Route1
    • Tetraethyl hexane-1,6-diylbis(phosphonate)|CS-0368303
      5391-92-4
    • ~%
    • In-stock
      Hexane-1,6-diyldiphosphonic acid|CS-0115747
      4721-22-6

    References

    • Kosolapoff,G.M.; Brown,A.D. Journal of the Chemical Society [Section] C: Organic, 1966 , p. 757 - 759
  • Route2
    • In-stock
      1,6-Dibromo-n-hexane|CS-0015831
      629-03-8
    • null|null
      122-52-1
    • ~89%
    • In-stock
      Hexane-1,6-diyldiphosphonic acid|CS-0115747
      4721-22-6

    References

    • Villemin, Didier; Moreau, Bernard; Kaid, M'Hamed; Didi, Mohamed Amine Phosphorus, Sulfur and Silicon and the Related Elements, 2010 , vol. 185, # 8 p. 1583 - 1586
  • Route3

    References

    • Horne; Blanchard Journal of the American Chemical Society, 1996 , vol. 118, # 50 p. 12788 - 12795

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H290-H314
Precautionary Statements : P234-P260-P264-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501

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Computational Chemistry Data

  • TPSA   115.06
  • LogP   0.9022
  • H_Acceptors   2
  • H_Donors   4
  • Rotatable_Bonds   7

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