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CS-W001157 4
Total: USD 88.00

6-Methylpiperidin-2-one

  • CAS No. 4775-98-8

  • Cat. No. CS-0009358
  • Molecule weight113.16
  • Purity≥96%
  • MDL No.MFCD00127922

*For research and further manufacturing use only, not for direct human use.

6-Methylpiperidin-2-one|CS-0009358

Structure of 4775-98-8

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General Information

  • CAS No. 4775-98-8
  • Cat. No. CS-0009358
  • Purity ≥96%
  • MDL No. MFCD00127922
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁NO
  • Molecular Weight 113.16
  • Synonym(s) Methylpentanonisoxim [German]
  • SMILES O=C1NC(C)CCC1

Description

6-Methylpiperidin-2-one is a sterically hindered, bench-stable heterocyclic ketone featuring a nitrogen-rich scaffold with enhanced solubility in polar organic solvents. This cyclic amide integrates readily into complex molecular architectures, serving as a key building block for bioactive compound synthesis and medicinal chemistry campaigns.

Application

6-Methylpiperidin-2-one serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to nitrogen-containing scaffolds. Its cyclic ketone functionality facilitates stereoselective reductions, nucleophilic additions, and transition-metal-catalyzed couplings. The molecule exhibits excellent bench stability, ease of purification, and compatibility with diverse functional groups, making it well-suited for iterative synthesis campaigns and API development workflows.

Synthesis

  • Route1
    • null|null
      98552-93-3
    • ~99%
    • In-stock
      6-Methylpiperidin-2-one|CS-0009358
      4775-98-8

    References

    • Nagasaka, Tatsuo; Kato, Hiroki; Hayashi, Hideki; Shioda, Masako; Hikasa, Hiromi; Hamaguchi, Fumiko Heterocycles, 1990 , vol. 30, # 1 p. 561 - 566
  • Route2
    • In-stock
      Glutarimide|CS-W023103
      1121-89-7
    • null|null
      917-64-6
    • ~80%
    • In-stock
      6-Methylpiperidin-2-one|CS-0009358
      4775-98-8

    References

    • Maldaner, Adriano O.; Pilli, Ronaldo A. Tetrahedron, 1999 , vol. 55, # 47 p. 13321 - 13332
  • Route3
    • null|null
      1215111-91-3
    • ~%
    • In-stock
      6-Methylpiperidin-2-one|CS-0009358
      4775-98-8

    References

    • Nissan Chemical Industries, Ltd. Patent: EP2336104 A1, 2011 ; Location in patent: Page/Page column 125 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   0.675
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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