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Structure of 478375-42-7
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Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate features a boronate ester group flanked by a methyl acrylate moiety, enabling efficient Suzuki-Miyaura coupling under mild conditions. This bench-stable reagent integrates readily into complex molecule synthesis, offering predictable regioselectivity and compatibility with diverse functional groups.
Methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate serves as a versatile boron-containing building block for Suzuki-Miyaura cross-coupling reactions. The tetramethylboronate group exhibits high stability, excellent functional group tolerance, and reliable coupling efficiency under standard conditions. It facilitates the construction of biaryl and substituted aryl motifs commonly found in pharmaceutical and agrochemical scaffolds, enabling efficient C–C bond formation with aryl halides or pseudohalides. The methyl ester functionality provides additional handle for downstream transformations, enhancing its utility in synthetic sequences.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: