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Structure of 481075-59-6
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1-Bromo-3-iodo-5-(trifluoromethyl)benzene features a trifluoromethyl group that imparts strong electron-withdrawing character, while the bromo and iodo substituents enable sequential cross-coupling reactions. This ortho-disubstituted aromatic scaffold offers high reactivity in palladium-catalyzed transformations and exhibits bench-stable handling under inert conditions.
1-Bromo-3-iodo-5-(trifluoromethyl)benzene serves as a versatile diaryl building block for palladium-catalyzed cross-coupling reactions, enabling efficient access to functionalized biaryl scaffolds. The orthogonal reactivity of bromo and iodo groups facilitates sequential coupling under mild conditions, while the trifluoromethyl group imparts enhanced metabolic stability and lipophilicity—key attributes in medicinal chemistry. Bench-stable and readily purified by column chromatography, it functions reliably in standard Suzuki, Stille, and Negishi transformations.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: